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Structural changes of the human pineal gland in relation to hypoxy duration

By:   |   Jul 08, 2018   |   Views: 14   |   Comments: 0

V. Dokov, W. Dokov D. Radoinova
Department of Pathology, *Department of Forensic Medicine, Medical University of Varna, Bulgaria

Abstract: PG’s of the 1st group were significantly (t=7,3, P<0,05) heavier (168.15±42.15 mg) than 2nd (111.67±42.94 mg) and 3rd
(115.61±50.58 mg). In the cases of ARI the density is significantly higher than those of MAH (2.6±1.77 kg/m3) and CRIE (3.45±1.97 kg/m3). In the cases of CRIE the stroma increases and the pseudolobs are atrophic.
The frequency of well shaped pseudolobs is significantly higher in the 3rd (58.92%) than in the 1st (26.92%) and 2nd group (25%). The frequency of glial prolifration in MAH (46.15%) and ARI (64.29%) is significantly lower (t=2,39, P<0,05) than CRIE(76.47%).

Introduction: Morphological data of the relation of hypoxy to the structure of the human pineal gland (PG) are very few.
The aim of this study was to investigate the morphological changes of PG in relation to acute and chronic hypoxy.

Methods: Seventy three PG’s were observed – 56 male and 17 female.
Length, width, weight and density of the glands were measured. To determine the duration of hypoxia, the cases were separated in three
groups: 1st – 26 died of mechanical asfixia of hanging (MAH), mean age
57.24 ± 11.34; 2nd – 28 died of acute respiratory insufficience (ARI), mean age 51.5 ± 10.93; 3rd – 19 died of chronic respiratory insufficience with exacerbation (CRIE), mean age 52.33 ±13.06. Paraffin slides were stained with hematoxylin–eosine and Azan.

Results: PG’s of the 1st group were significantly (t=7,3, P<0,05) heavier (168.15±42.15 mg) than 2nd (111.67±42.94 mg) and 3rd
(115.61±50.58 mg). In the cases of ARI the density is significantly higher than those of MAH (2.6±1.77 kg/m3) and CRIE (3.45±1.97 kg/m3). In the cases of CRIE the stroma increases and the pseudolobs are atrophic.
The frequency of well shaped pseudolobs is significantly higher in the 3rd (58.92%) than in the 1st (26.92%) and 2nd group (25%). The frequency of glial prolifration in MAH (46.15%) and ARI (64.29%) is significantly lower (t=2,39, P<0,05) than CRIE(76.47%).

Conclusions: Continuous hypoxia in the cases of CRIE developes gliosis and increases the relative share of well shaped pseudolobs of PG and proliferation of stroma and different stages of pseudolobar atrophy.
The acute hypoxia of MAH and ARI does not develope structural changes of the PG.

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